Clindamycin is a lincosamide antibiotic, which is chlorinated derivative of lincomycin with a primarily bacteriostatic action against Gram-positive organisms and a wide range of anaerobic pathogens, as well as some antiprotozoal actions. Lincosamides such as clindamycin bind to the 50S subunit of the bacterial ribosome similarly to macrolides such as erythromycin and inhibit the early stages of protein synthesis. It is usually used when other drugs are unsuitable, in the treatment of anaerobic, staphylococcal and streptococcal infections, and in the prophylaxis of endocarditis. It has also been tried in Pneumocystis carinii pneumonia and in protozoal infections such as babesiosis, malaria and toxoplasmosis.
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